Publications

Lab members are bold.

2025
Fitzgerald, J.C., Bremm, A. (2025).
A structural switch reveals how to disarm USP30 and unlock mitophagy.
Nature Structural & Molecular Biology
32(9): 1586–1588.
DOI PubMed
Editorial / News & Views
2024
Bajdzienko, J., Bremm, A. (2024).
Mammalian pexophagy at a glance.
Journal of Cell Science
137(9): jcs259775.
DOI PubMed
Review
2023
Mende, H., Khatri, A., Lange, C., Poveda-Cuevas, S.A., Tascher, G., Covarrubias-Pinto, A., Löhr, F., Koschade, S.E., Dikic, I., Münch, C., Bremm, A., Brunetti, L., Brandts, C.H., Uckelmann, H., Dötsch, V., Rogov, V.V., Bhaskara, R.M., Müller, S. (2023).
An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant.
Cell Reports
42(12): 113484.
DOI PubMed
Research Article
Hertel, A., Eimer, S., Bremm, A. (2023).
LAMTOR1 ubiquitination restricts its interaction with the vacuolar-type H+-ATPase, promotes autophagy and is controlled by USP32.
Autophagy
19(8): 2406–2407.
DOI PubMed
Comment / Highlight
de Oliveira Freitas Machado, C., Schafranek, M., Brüggemann, M., Hernández Cañás, M.C., Keller, M., Di Liddo, A., Brezski, A., Blümel, N., Arnold, B., Bremm, A., Wittig, I., Jaé, N., McNicoll, F., Dimmeler, S., Zarnack, K., Müller-McNicoll, M. (2023).
Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia.
Nucleic Acids Research
51(2): 870–890.
DOI PubMed
Research Article · Free PMC
2022
Hertel, A., Martins Alves, L., Dutz, H., Tascher, G., Bonn, F., Kaulich, M., Dikic, I., Eimer, S., Steinberg, F., Bremm, A. (2022).
USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction.
Cell Reports
41(10): 111653.
DOI PubMed
Research Article
2021
Basic, M., Hertel, A., Bajdzienko, J., Bonn, F., Tellechea, M., Stolz, A., Kern, A., Behl, C., Bremm, A. (2021).
The deubiquitinase USP11 is a versatile and conserved regulator of autophagy.
Journal of Biological Chemistry
297(5): 101263.
DOI PubMed
Research Article · Free PMC
2020
Bremm, A. (2020).
Hug and hold tight: Dimerization controls the turnover of the ubiquitin-conjugating enzyme UBE2S.
Science Signaling
13(654): eabd9892.
DOI PubMed
Editorial
Mader, J., Huber, J., Bonn, F., Dötsch, V., Rogov, V.V., Bremm, A. (2020).
Oxygen-dependent asparagine hydroxylation of the ubiquitin-associated (UBA) domain in Cezanne regulates ubiquitin binding.
Journal of Biological Chemistry
295(8): 2160–2174.
DOI PubMed
Research Article · Editor's Pick & Cover Image · Free PMC
2019
Wegner, M., Diehl, V., Bittl, V., de Bruyn, R., Wiechmann, S., Matthess, Y., Hebel, M., Hayes, M.G., Schaubeck, S., Benner, C., Heinz, S., Bremm, A., Dikic, I., Ernst, A., Kaulich, M. (2019).
Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome.
eLife
8: e42549.
DOI PubMed
Research Article · Free PMC
Fottner, M., Brunner, A.D., Bittl, V., Horn-Ghetko, D., Jussupow, A., Kaila, V.R.I., Bremm, A., & Lang, K. (2019).
Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase.
Nature Chemical Biology
15(3): 276–284.
DOI PubMed
Research Article
2016
Akutsu, M., Dikic, I., Bremm, A. (2016).
Ubiquitin chain diversity at a glance.
Journal of Cell Science
129(4): 875–880.
DOI PubMed
Review
2015
Moniz, S., Bandarra, D., Biddlestone, J., Campbell, K.J., Komander, D., Bremm, A., Rocha, S. (2015).
Cezanne regulates E2F1-dependent HIF2α expression.
Journal of Cell Science
128(16): 3082–3093.
DOI PubMed
Research Article · Free PMC
2014
Dikic, I., Bremm, A. (2014).
DUBs counteract Parkin for efficient mitophagy.
The EMBO Journal
33(21): 2442–2444.
DOI PubMed
News & Views / Highlight
Bremm, A., Moniz S., Mader, J., Rocha S., Komander, D. (2014).
Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.
EMBO Reports
15(12): 1268–1277.
DOI PubMed
Research Article · Free PMC
2012
Bremm, A., Komander, D. (2012).
Synthesis and analysis of K11-linked ubiquitin chains.
Methods in Molecular Biology
832: 85–96.
PubMed
Methods
2011
Bremm, A., Komander, D. (2011).
Emerging roles for Lys11-linked polyubiquitin in cellular regulation.
Trends in Biochemical Sciences
36(7): 355–363.
DOI PubMed
Review
2010
Bremm, A., Freund, S.M.V., Komander, D. (2010).
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.
Nature Structural & Molecular Biology
17(8): 939–947.
DOI PubMed
Research Article · Free PMC
2009
Kulathu, Y., Akutsu, M., Bremm, A., Hofmann, K., Komander, D. (2009).
Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.
Nature Structural & Molecular Biology
16(12): 1328–1330.
DOI PubMed
Research Article
Markson, G., Kiel, C., Hyde, R., Brown, S., Charalabous, P., Bremm, A., Semple, J., Woodsmith, J., Duley, S., Salehi-Ashtiani, K., Vidal, M., Komander, D., Serrano, L., Lehner, P., Sanderson, C.M. (2009).
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
Genome Research
19(10): 1905–1911.
DOI PubMed
Research Article · Free PMC
2008
Bremm, A., Walch, A., Fuchs, M., Mages, J., Duyster, J., Keller, G., Hermannstädter, C., Becker, K.F., Rauser, S., Langer, R., von Weyhern, C.H., Höfler, H., & Luber, B. (2008).
Enhanced activation of epidermal growth factor receptor caused by tumor-derived E-cadherin mutations.
Cancer Research
68(3): 707–714.
DOI PubMed
Research Article

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